Healor logo
Raj Singh MD
September 10, 2023

What Is Semaglutide and How Does It Promote Weight Loss?

What Is Semaglutide and How Does It Promote Weight Loss

Discover What Is Semaglutide and How Does It Promote Weight Loss. Weight loss is a common goal for many individuals, but traditional methods such as exercise and dieting are not always enjoyable or effective. In some cases, alternative approaches are necessary. Semaglutide is one such option that has gained attention for its potential to promote weight loss. But what exactly is semaglutide, and how does it work?

What Is Semaglutide?

Semaglutide belongs to a class of medications called glucagon-like peptide-1 receptor agonists (GLP-1 RAs). Originally developed to treat type 2 diabetes, experts have also found that semaglutide significantly impacts weight loss. It is a synthetic form of a naturally occurring hormone called glucagon-like peptide-1 (GLP-1), released by the intestines after eating. GLP-1 is crucial in regulating blood sugar levels, insulin secretion, and appetite.

Semaglutide Injections

Semaglutide is typically administered through subcutaneous injections, where a small needle delivers the medication just below the skin. The injection can be self-administered once a week. Following the prescribed dosage and administration instructions a healthcare professional provides is essential.

How Does It Promote Weight Loss?

Semaglutide promotes weight loss through various mechanisms. Here are three of the most significant effects as it relates to weight management:

Activates GLP-1 Receptors

Firstly, it works by activating GLP-1 receptors in the brain, which helps to reduce appetite and increase the feeling of fullness. It leads to a decreased caloric intake and an overall reduction in body weight.

Slows Down Food Movement

Additionally, semaglutide slows down the movement of food through the stomach, which increases the time it takes for the stomach to empty. This delay in gastric emptying helps to regulate the release of sugar into the bloodstream, preventing sharp spikes in blood sugar levels and promoting better glucose control.

Improves Energy While Burning Calories and Fat

Moreover, experts have found semaglutide to increase energy expenditure, or the number of calories the body burns at rest. Increased energy expenditure and decreased caloric intake lead to burning fat, helping individuals achieve their weight loss goals.

What Are the Benefits of Taking Semaglutide for Weight Loss?

Semaglutide is an FDA-approved medication for weight loss. It has been associated with improvements in many other parameters, reducing blood pressure, improving blood sugar control, and decreasing the risk of developing type 2 diabetes.

These benefits make semaglutide a potentially valuable option for individuals who are overweight or have obesity-related health conditions. People using this medication can expect to experience the following:

Suppressed Appetite

Semaglutide suppresses the appetite, reducing cravings and hunger. It helps reduce caloric intake and may help individuals stick to their diet and exercise plan.

Weight Loss (At Least Two Pounds a Week)

Semaglutide can cause an average weight loss of two to four pounds weekly. This benefit is due to its appetite suppression effects and ability to slow gastric emptying and increase energy expenditure. Weight loss can be observed after four weeks of treatment, but it can take several months to reach the maximum effect. Adults can lose about 15.9 kilograms after 68 weeks.

Improved Insulin Resistance

The medication improves insulin resistance, which is vital for individuals with pre-diabetes or at risk of developing type 2 diabetes. It helps regulate the release of sugar into the bloodstream and can help reduce high blood glucose levels.

Boosted Energy

Semaglutide can boost energy levels, making participating in physical activity and exercise easier. As a result, individuals may feel less fatigued and more motivated to stay active.

Fat Burning

The combination of increased energy expenditure and calorie restriction may lead to fat burning, allowing individuals to reach their weight loss goals.

Is Semaglutide Safe?

As an FDA-approved medication, semaglutide has been proven to be generally safe and well-tolerated in clinical trials. Semaglutide is available in various dosage forms, including tablets and injections, and users must adhere to the instructions for proper use and administration. However, like any medication, it may have side effects and risks, which should be considered and discussed with a healthcare professional.

Who Can and Cannot Use Semaglutide For Weight Loss?

Semaglutide is primarily approved for individuals with a body mass index (BMI) of 30 or higher or those with a BMI of 27 or higher with obesity-related health conditions. It is important to note that semaglutide should be part of a comprehensive weight management plan, including healthy eating, regular physical activity, and behavior changes.

Before taking the medication, the care team must know about any of the following conditions:

  • Endocrine tumors (MEN 2)
  • Vision problems
  • Gallbladder disease
  • Depression or mental health disease
  • Pancreatitis
  • Kidney disease
  • Intestine problems
  • Thyroid cancer
  • Allergies
  • Pregnancy
  • Breastfeeding

It is also crucial to inform the care team about insulin and other medications for diabetes. Semaglutide is not suitable for everyone and should be taken only with the guidance of a healthcare professional. Experts must thoroughly review the individual’s medical history to ensure it is safe to take semaglutide.

What Are the Side Effects of Semaglutide?

As mentioned earlier, semaglutide is generally safe and well-tolerated in clinical trials. However, like any medication, it may have side effects. Commonly reported side effects include the following:


The first few doses of semaglutide may cause temporary dizziness. Individuals with this side effect are advised not to drive or operate machinery until they can safely do so.


Some individuals may experience fatigue after taking semaglutide. If this occurs, one must get plenty of rest and take the medication when they can sleep or rest.

Gastrointestinal Issues

Some people may also experience nausea, vomiting, diarrhea, or constipation. It may help to take the medication with food and drink plenty of fluids to reduce the risk of these side effects.


Headaches are another common side effect of semaglutide. Taking ibuprofen or paracetamol may help reduce the discomfort.

Stomach Issues

Some people may experience a feeling of fullness or bloating. Drinking plenty of fluids and eating smaller, more frequent meals may help reduce these symptoms.

Reporting any side effects experienced while taking semaglutide to the healthcare provider is essential. Suppose the side effects become too severe or are causing significant distress. In this case, the healthcare provider may need to adjust the dose or switch to another medication.

Other side effects that one must immediately report to the care team include the following:

  • Allergic reactions
  • Vision problems
  • Dehydration
  • Gallbladder problems
  • Heart palpitations
  • Kidney injury
  • Pancreatitis
  • Depression
  • Thyroid cancer

Awareness of potential drug interactions when taking semaglutide can help reduce the risk of serious complications. Individuals must inform the healthcare provider about all medications they’re taking, including prescription, over-the-counter drugs, vitamins, and herbal supplements.

Trust Professionals When Using Semaglutide for Weight Loss

Before considering semaglutide or any other weight loss medication, it is best to consult a healthcare professional who can evaluate your specific situation and determine if it is a suitable option for you. They will assess your medical history, current health conditions, and potential risks and benefits associated with semaglutide use.

While semaglutide shows promise as an effective weight loss medication, it is essential to approach weight management holistically. A balanced diet, regular exercise, and healthy lifestyle choices remain crucial for long-term weight management and well-being. By working closely with healthcare professionals and implementing a comprehensive plan, individuals can optimize their weight loss journey and improve their health.

Leave a Reply

Your email address will not be published. Required fields are marked *

Get in Touch

© 2024 HEALOR ™ All rights reserved.
Powered by Healthstro