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What Is Post Orgasmic Illness Syndrome (POIS)?
When male sexual health is discussed, the focus is usually on erectile dysfunction, premature ejaculation, or delayed ejaculation. Post-orgasmic illness syndrome (POIS) is a rare and often misunderstood condition in which men experience severe physical, cognitive, and emotional symptoms following ejaculation or orgasm. These symptoms can significantly impair quality of life and lead many men to avoid sexual activity altogether.
At HEALOR® in Las Vegas, NV, our physicians evaluate complex male sexual health conditions, including POIS, through a comprehensive and individualized approach.
When Do POIS Symptoms Appear?
Symptoms typically begin within minutes to hours after orgasm and may persist for several days. For many patients, the severity of symptoms interferes with work, relationships, and mental health.
If post-ejaculatory symptoms overlap with erectile or libido concerns, further evaluation is recommended:
👉 Erectile Dysfunction Evaluation
Common Symptoms of Post-Orgasmic Illness Syndrome
Symptoms vary between individuals but often include:
Flu-like symptoms
- Extreme fatigue
- Fever or chills
- Muscle aches
- Headaches
Cognitive symptoms
- Brain fog
- Difficulty concentrating
- Memory impairment
- Irritability
Allergic-type symptoms
- Sneezing
- Nasal congestion
- Itching
Gastrointestinal symptoms
- Diarrhea
- Abdominal discomfort
Skin symptoms
- Rash
- Flushing
Because these symptoms overlap with hormonal, immune, and inflammatory conditions, a detailed evaluation is essential.
What Causes Post-Orgasmic Illness Syndrome?
The exact cause of POIS is not fully understood. Current evidence suggests it may involve an autoimmune or allergic-type reaction to components released during ejaculation.
Because hormones play a role in immune regulation, testosterone imbalance may be a contributing factor. Learn more about hormone-related symptoms here:
👉 What Is Hormonal Imbalance?
Can Females Develop POIS?
Although POIS has been reported in females, most documented cases involve males, and the majority of research focuses on male patients.
Is POIS Linked to Masturbation?
POIS symptoms occur after ejaculation, whether through intercourse, masturbation, or nocturnal emissions (wet dreams).
What Is the Typical Age of Onset?
Available data suggests symptoms usually begin during the teenage years, though diagnosis is often delayed for many years.
How Is Post-Orgasmic Illness Syndrome Diagnosed?
There is no single diagnostic test. POIS is a clinical diagnosis based on symptom patterns.
At HEALOR®, evaluation often includes:
- Complete blood count (CBC)
- Comprehensive metabolic panel
- Total and free testosterone
- Thyroid testing (TSH)
- Estrogen levels
- Inflammatory markers (ESR, CRP)
- Interleukin Levels
- Autoimmune and Allergy workup
If testosterone deficiency is identified, further assessment may be required:
👉 How to Know If You Need Hormone Therapy
Is Low Testosterone Linked to POIS?
Many men with POIS have low or borderline-low testosterone levels. Testosterone deficiency has been associated with increased immune activation, which may worsen inflammatory or autoimmune responses.
Raising testosterone levels—either through testosterone-supportive therapies or targeted supplements—has been shown to improve symptoms in some patients.
Learn more about testosterone’s role in male health:
👉 Hormone Imbalance and Male Sexual Health
Would a Vasectomy Help POIS?
Unfortunately, vasectomy does not improve POIS symptoms, as the reaction is believed to be immune-mediated rather than related to sperm transport.
How Is Post-Orgasmic Illness Syndrome Treated?
There is currently no definitive cure, but symptom-management strategies may include:
- Antihistamines (e.g., fexofenadine, diphenhydramine)
- Testosterone-supportive therapies (e.g., hCG, clomiphene citrate)
- Anti-inflammatory strategies
- Selective serotonin reuptake inhibitors (SSRIs) in select cases
⚠️ Testosterone replacement therapy (TRT) is generally avoided in young men due to fertility concerns. If TRT is used, it is often combined with clomiphene citrate to preserve testicular function.
Emerging Treatment: Omalizumab for POIS
Omalizumab is a monoclonal antibody approved for allergic asthma and IgE-mediated disorders. Because POIS may involve an allergic mechanism, case reports suggest potential benefit, though large-scale trials are lacking.
Limitations include:
- Weekly injections
- High cost ($2,000–$3,000 per week)
This therapy remains experimental for POIS.
Get Help for POIS in Las Vegas
Post-orgasmic illness syndrome can be debilitating—but you are not alone, and evaluation can uncover treatable contributors such as hormone imbalance or inflammation.
📞 Contact HEALOR® to schedule a confidential consultation with Dr. Raj Singh and our primary care team in Las Vegas, NV. Our primary care doctors in Las Vegas at HEALOR® can help! Contact us today.
Are you only in the US or in other countries too? Interested to know home remedies that can help handle this situation.
Hi SB, I just wanted to say a big thank you for your comment. It’s so amazing to know that we have visitors from all around the world who trust us. Although we are based in the US we have clients all over the world who use our virtual consultations to stay connected. It’s truly a global community!
Now, let’s talk about something really exciting – raising testosterone levels and its impact on post orgasmic illness syndrome. This is an area where we’ve seen some incredible results! It turns out that boosting testosterone levels can really make a difference in managing the symptoms of this syndrome.
At our clinic, we’ve developed a range of treatment regimens that specifically focus on increasing the natural production of testosterone in the body. We believe that by encouraging the body’s own testosterone production, we can provide a more sustainable and long-term solution for our clients.
At home you can try ashwagandha. This powerful herb has been used for centuries in traditional medicine and has shown promising results in boosting testosterone. Another supplement we recommend is shilajit, which has been used in Ayurvedic medicine for its testosterone-boosting properties. You can also try other adrenal support supplements.
All the best!
HI,
I am from India, male person with age of 36years and had the masturbation habit like doing alternative days from last 18 years.
1. Initially no side effects but from the 2nd year start facing memory and concentration issues.
2. Same phase continued for several years then started facing heat, cold, cramps after doing the masturbation. So far 10 years masturbation phase completed.
3. Now started seeing fivers with elevated WBC count of 16K, low vitamins(b12, D) but not able to stop habit because of mental compulsion and with 6 months of homeo treatment able recover but still WBC count at 12k
4. Still habit continued because of mental compulsion and feel the heat symptoms for 2 days and if i give pause for 4-5 days things were back to normal but allways WBC count at 15-17K when ever i tested occasionally. This is for the last 8 years
5. From last 30 days starting seeing itching and fiver symptoms along with WBC at 17k and using the anti-histamines for itching.
6. From last 10 days stopped doing masturbation and feeling recovered from fatigue, memory, concentration but still facing itching and fiver symptoms with WBC at 17K.
Why WBC count not reduced even after 10 days and any suggestions to reduce them along with itching and fiver symptoms.
Hi Ethan,
Thank you for a very detailed timeline of issues that you have been facing. Elevated white blood cell count and associated fevers generally suggest an underlying infection or an autoimmune process. My recommendation would be to get an autoimmune panel to look for autoimmune diseases and also see a hematologist for a possible bone marrow biopsy as persistent elevated white blood count for several years can suggest an underlying bone marrow disorder. we also see itching, fever and elevated blood count in a bone marrow disorder called chronic myeloid leukemia or CML. This is something that definitely needs to be excluded. You need to see a qualified doctor like an internal medicine physician or a blood specialist like a hematologist to investigate this further. I hope you feel better and all the best to you. Please do post your response once you have seen the specialist.
Good day doctor! I’m currently suffering from this same fate POIS, following your responses to some comments I really appreciate your efforts.
Doctor please, my question are:
1. can one actually stop this masturbation habits? If the answer is yes, please ???? what are the ways out?
2. Can one continuing experiencing this POIS when married? ????????
Hi Thanks for the comment. You have to explore the reasons behind the compulsive masturbation habits. Is it to relive stress, anxiety or lack of sexual satisfaction with partner. I would recommend spoeaking with a therapist or joining support groups. Porn is another big reason for this habit. I posted a video a while back that you might find helpful https://youtu.be/IRJ5ML6HYuA?si=2KoRHgyGwMHHyYPE
POIS is related to ejaulation and being married or single unfortunately won’t change that fact. Having a healthy open conversation with the partner is the best way to address this
Alright ????.
Thanks alot for your reply doctor ????????????
I read the information on Omalizumab a drug administered by infection to treat Post Orgasmic Illness Syndrome.
However the side effects can cause heart troubles, nausea and dizziness. What is your experience so far?
Hi henry, Thanks for the comment. Omalizumab is monoclonal antibody that is approved for use in asthma and works by lowering IgE and downregulates mast cells thereby reduce allergic response to the allergan. Since POIS is postulated to be an allergic disorder this has been tested in POIS and other allergy mediated disorders. There is liomited data and only few case reports has been published. I have no experiece using omalizumab for POIS however I am excited for this new treatment option for POIS.
Good Day,
I’m so happy I found this website and glad to know I am not alone. I’ve been suffering from POIS since having covid in 2020. I take multi vitamins, b6 b12 Coenzyme Complex along with Tumeric Curcumin and vitamin c. The urologist told me to take a clartin or allegra before the orgasm and he prescribed Diclofenac which I take with Clartin or allegra. After the orgasm I have taking Bromelain vitamins along with Diclofenac, and also a b6 b12 coenzyme vitamin. It does help however the next day I am still fatigue and have mood swings. It’s anything will get me irritated.
I’ve tried eating dark chocolate the night before and that does stabiliz my mood the next day however with eating sugar so late I am still tired and fatigue. Takkng a nap the next day really helps. Is there anything healthy that I can take to help with the mood swings and fatigue? I’m a little cautious with Ashwagandha only because I am a sober and drug free guy in recovery and I don’t want to take anything that alters my mood. If that make sense? Any suggestions
Thanks for your comment. Based on limited information about your medical history, I do not see any issue using Ashwagandha. Other option would be a trial of buspirone to improve fluctuations in mood.
Thank you so much Dr. Raj! I wish I could meet with you as doctor to go over my medical history. And to smooth out these symptoms but not sure if my insurance will cover. I am in the USA in Washington DC.
I will check out Ashwagandha. Is it best to be taking directly after ejaculation or the next day?
We have many out of state patients and certain insurance plans do cover out of state visits based on necessity. We also have cash pay memberships that can be used. Please call or text 702-362-2273 and our team can assist you. Ashwagantha is to be used daily
Hi Dr. Singh, I have been suffering with POIS for years , wasn’t sure what was going on with me , heard Rush Limbaugh talk about the Doctor in Ireland, who said he had found the culprit to POIS , that’s when I realized that I had POIS , to make long story short, been trying to get Doctors, to try and help, but none have lent a serious ear . It affects me differently sometimes, but I had my Testosterone level checked after seeing, that a 26 YO had some good results with Testosterone Gel , I got a hold of a Urologist. And did Testosterone check and I was low, so found some relief but not always a sure fix, I still get cognitive issues that last for days , sometimes I even get itchy hemorrhoids. and my eyes get itchy also.
The POIS doesn’t hit me the same day after ejaculation. It will be the following day , and from there on I am so tired for several days , and its seems that my cognitive awareness is still diminished.
And also seen where someone said that it is candida yeast infection that is the underlying infliction, he cured his self by staring the candida’s and that means, stop eating about everything, including coffee…
But I’m thinking, that it isn’t the allergic reaction to the semen, but instead the chemicals that are released, from the brain , because I have held back on the orgasm , but still release some semen , and did not get any POIS , only when I have a complete orgasm…
Hi Roger,
Thank you for taking the time to provide a detailed comment. It is important to note that Post-Orgasmic Illness Syndrome (POIS) is not widely recognized in the medical community, and as a result, many medical providers may not be aware of its existence. This lack of awareness contributes to the limited understanding we currently have of this syndrome. There are various theories regarding the exact cause of POIS, but further research is needed to provide a definitive answer.
In terms of treatment options, I would advise against using testosterone for young patients due to the potential risks of testicular atrophy and infertility. If you have not yet completed your family planning, it would be best to explore alternatives such as testosterone boosting supplements rather than directly supplementing with the hormone itself. These supplements can help optimize testosterone levels without the associated risks.
Additionally, I always recommend considering additional testing, such as checking thyroid hormone levels , ESR and C-reactive protein. This is because hormonal imbalances or deficiencies in other areas of the body can contribute to symptoms similar to those experienced in POIS. By conducting thorough testing, we can gain a better understanding of your overall hormonal profile and identify any underlying issues that may be contributing to your symptoms.
Regards,
Dr. Raj Singh
I’m looking for possible doctors or anyone to help treat this. I am 99.9% sure I have this and it started with my COVID infection in August 2020. Please help me.
Hi Jon, Next step would be to setup a virtual consultation for advice. Please fill out the contact form on healor.com and our team will contact you
Hello sir I’m suffering from pois from 6 to 7 yers
My symptoms are anxiety, mental fog and severe back pain I’m also suffering inflammatory bowel disease and I have taken treatment for IBD but my gut symptoms are more severe after ejaculation actually im also Doctor but no one believes that pois exists
Hello sir
I’m from India I’m suffering from pois from 6 to 7 years my symptoms are anxiety mental fog , back pain , decreased concentration, over sleepiness and I’m also suffering from inflammatory bowel disease and taking treatment for same but my gut symptoms are more severe after ejaculation
I have tested my testosterone level which was normal ESR was also normal but vit D is low
Actually I’m 25 yrs old and I’m also Doctor and no one believes that pois exists can you help me with this please
hello, thanks for the comment. Unfortunately, many medical providers are not aware of the condition and is much easier to dismiss a patient’s concern then learn more about it. I would still suggest using natural testosterone boosters such as ashwagantha, shilajeet etc to boost testosterone levels Even if your testosterone levels are coming back normal. And please seek the help of a different doctor who is more open minded and willing to address your concern
Hello, my husband and I have been married for 33 yrs, it’s been a life, I am very blessed to have him as my husband, and he’s also a wonderful father to our 4 children, now young adults. My question is that for many many years, my husband has been suffering from what we’ve believed to be is POIS. We could never get answers or treatment for what he has. Dr’s don’t know what this is, even his urologist. So how we found out about this was just recently. Now researching this illness has give us some hope of answers and treatment options. This illness has debilitated my husband both physically and mentally, emotionally and has caused some major issues with our intimacy together. I can recall when he was younger how sick he did get and would not be able to work or be at work. My husband is 50yrs old now, so dealing with this has not been an easy road of no knowing what to do or who to go to. Being intimate with my husband has created major disconnection, for fear of being seriously ill. All the symptoms go along with POIS, if you could please give us some information on who he can go see for treatment in the Albuquerque NM areas, it would be a God sent.
Thank you so kindly
The Mrs.
Hi Anna, thank you for your comment. Post orgasmic illness syndrome is a diagnosis of exclusion and requires a thorough evaluation. Many doctors are not aware of this disorder and I do not have any recommendations in your area. we do offer virtual evaluations. If this is something that will work for you please schedule an appointment on our website.